Autoimmunity in narcolepsy
نویسندگان
چکیده
منابع مشابه
The Autoimmunity Hypothesis in Narcolepsy
Since the finding in 1983 that narcolepsy-cataplexy has a strong genetic association with a particular HLA class II haplotype, it has been hypothesized that most sporadic cases result from autoimmunity. Recent evidence indicates that the disease results from the death of the small number of hypocretin (hcrt)-producing cells in the lateral hypothalamus, strongly suggesting that an autoimmune att...
متن کاملNarcolepsy: Autoimmunity or Secondary to Infection?
Narcolepsy is a sleep disorder that is characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. In the review presented here, we aim at focusing on the immunological aspects of the disease. Special attention will be given to the link between tumor necrosis factor-a (alpha) (TNF) and major histocompatibility class II (MHC II) antigens and on autoim...
متن کاملNarcolepsy with hypocretin/orexin deficiency, infections and autoimmunity of the brain.
The loss of hypothalamic hypocretin/orexin (hcrt) producing neurons causes narcolepsy with cataplexy. An autoimmune basis for the disease has long been suspected and recent results have greatly strengthened this hypothesis. Narcolepsy with hcrt deficiency is now known to be associated with a Human Leukocyte Antigen (HLA) and T-cell receptor (TCR) polymorphisms, suggesting that an autoimmune pro...
متن کاملMetamemory in narcolepsy.
People with narcolepsy consistently report diminished memory function attributable to the disorder, however, objective evaluations of memory performance in this clinical group remain inconclusive. Previous evaluations of these subjective experiences have been primarily anecdotal with subjects required to provide global assessments of their memory function. The present study aimed to evaluate su...
متن کاملNarcolepsy in identical twins.
Narcolepsy has been observed in chronic encephalitis, cerebral arteriosclerosis, brain tumour, and following trauma, but when these cases are excluded there remains a group without demonstrable brain pathology. The existence of this idiopathic group has been a controversial subject. Among the more impressive evidence is that suggesting a hereditary factor in idiopathic narcolepsy. To date this ...
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ژورنال
عنوان ژورنال: Current Opinion in Pulmonary Medicine
سال: 2017
ISSN: 1070-5287
DOI: 10.1097/mcp.0000000000000426